Table 1.
Representative oncogenic or tumor suppressive miRNAs in NSCLC.
| microRNA | Chromosome | Function | Expression | Targets | References |
|---|---|---|---|---|---|
| Let-7a | 9q22.3 | Tumor-suppressor | Down-regulation | BCL2L1, IGF1R, CCND1, KRAS | Chin et al., 2008 |
| 11q24.1 | |||||
| 22q13.31 | |||||
| Let-7b | 22q13.31 | Tumor-suppressor | Down-regulation | USP44, USP42, ATXN7L3, KRAS | Chin et al., 2008; Spolverini et al., 2017 |
| Let-7c | 21q21.1 | Tumor-suppressor | Down-regulation | ITGB3, MAP4K3, TRIB2, USP44, USP42, ATXN7L3, TGFBR3 | Kumar et al., 2014; Zhao et al., 2014; Spolverini et al., 2017 |
| miR-486 | 8p11.21 | Tumor-suppressor | Down-regulation | PI3KR1, IGF1R, IGF1, Pim-1, ARHGAP5, SNHG15, CDK14 | Peng et al., 2013; Pang et al., 2014; Wang, J. et al., 2014; Jin et al., 2018 |
| miR-134 | 14q32.31 | Tumor-suppressor | Down-regulation | CCND1, EGFR | Qin et al., 2016 |
| miR-218 | 4p15.31 | Tumor-suppressor | Down-regulation | EGFR, Slug, ZEB2, IL-6R, JAK3, HMGB1 | Zhang et al., 2013; Zhu et al., 2016; Shi et al., 2017; Yang et al., 2017 |
| 5q34 | |||||
| miR-326 | 11q13.4 | Tumor-suppressor | Down-regulation | CCND1, Sp1 | Sun et al., 2016; Wang et al., 2019 |
| miR-34 | 1p36.22 | Tumor-suppressor | Down-regulation | PD-L1, CDK4, HDM4, ZNF281, ZBP99, Snail1 | Kim et al., 2011; Hahn et al., 2013; Okada et al., 2014; Cortez et al., 2015; Feng et al., 2019 |
| 11q23.1 | |||||
| miR-200 | 1p36.33 | Tumor-suppressor | Down-regulation | ZEB1, ZEB2, PDL1, QKI, Foxf2, LOX, LOXL2, IL-8, CXCL1 | Pecot et al., 2013; Chen et al., 2014; Kundu et al., 2016; Peng et al., 2017, 2019; Kim et al., 2019 |
| 12p13.31 | |||||
| miR-520 | 19q13.42 | Tumor-suppressor | Down-regulation | VEGF | Zhou et al., 2019 |
| miR-16 | 3q25.33 | Tumor-suppressor | Down-regulation | MEK1, FEAT, Bcl-2 | Chatterjee et al., 2015 |
| miR-340 | 5q35.3 | Tumor-suppressor | Down-regulation | PUM1, PUM2, ZNF503, CDK4, RAB27B | Fernandez et al., 2015 |
| miR-26 | 3p22.2 | Tumor-suppressor | Down-regulation | ITGβ8, HMGA1, MALT1 | Chen et al., 2016 |
| 2q35 | |||||
| miR-196b | 7p15.2 | Oncogene | Up-regulation | GATA6, TSPAN12, FAS | Huang et al., 2020; Liang et al., 2020 |
| Tumor-suppressor | Down-regulation | Runx2, LIN28, FOS, UGT2A1 | Tellez et al., 2016; Bai et al., 2017 | ||
| miR-21 | 17q23.1 | Oncogene | Up-regulation | PDCD4, SOCS1, SOCS6, PTEN, Apaf11, RhoB, Faslg, Spry1, Spry2, BTG2 | Hatley et al., 2010; Zhang et al., 2010; Ma et al., 2011; Xue et al., 2016 |
| miR-31 | 9p21.3 | Oncogene | Up-regulation | CDK5, PTEN, p70S6K, ERK, AKT, RASA1, SPRY, SPRED | Meng et al., 2013; Edmonds et al., 2016 |
| miR-224 | Xq28 | Oncogene | Up-regulation | TUSC3, CASP3, CASP7, TNFAIP1, SMAD4, p21, TXNIP, PTEN | Knoll et al., 2014; Wang et al., 2014; Cui et al., 2015a,b; Jeon et al., 2018 |
| miR-155 | 21q21.3 | Oncogene | Up-regulation | SOCS1, SOCS6, PTEN, TAB2, TP53 | Xue et al., 2016; Van Roosbroeck et al., 2017; Wan et al., 2019 |
| miR-1246 | 2q31.1 | Oncogene | Up-regulation | MT1G, DR5 | Kim et al., 2016; Yuan et al., 2016; Zhang et al., 2016 |
| miR-210 | 11p15.5 | Oncogene | Up-regulation | E2F3, SDHD, FGFRL1, VMP-1, RAD52, | Puisségur et al., 2011; Cui H. et al., 2015 |
| miR-221/222 | Xp11.3 | Oncogene | Up-regulation | APAF1, SOCS3, TIMP2, TIMP3, PTEN, p27 | Garofalo et al., 2009, 2011; Wei et al., 2017 |
| miR-17/92 | 13q23.1 | Oncogene | Up-regulation | NR2C2, HIC1, NR1I2, PTH, p38α, BCL2L11, PPP2R5E | Borkowski et al., 2015; Guinot et al., 2016; Baumgartner et al., 2018 |