TABLE 3.

GO classifications of proteins differing in abundance between lean and obese muscle.

Classification	Total	Observed	Expected	Fold enrichment	Bonferroni P
Glycolysis (GO:0006096)	34	11	0.64	17.13	2.26E-08
Tricarboxylic acid cycle (GO:0006099)	27	5	0.51	9.81	4.44E-02
Fatty acid beta-oxidation (GO:0006635)	34	6	0.64	9.35	1.32E-02
Oxidative phosphorylation (GO:0006119)	51	9	0.96	9.35	1.86E-04
Generation of precursor metabolites and energy (GO:0006091)	224	35	4.23	8.27	9.60E-19
Muscle contraction (GO:0006936)	154	18	2.91	6.19	4.06E-07
Respiratory electron transport chain (GO:0022904)	155	16	2.93	5.47	1.75E-05
Protein targeting (GO:0006605)	158	14	2.98	4.69	6.67E-04
Chromatin organization (GO:0006325)	263	22	4.97	4.43	2.72E-06
Fatty acid metabolic process (GO:0006631)	181	13	3.42	3.8	1.30E-02
Translation (GO:0006412)	323	18	6.1	2.95	1.41E-02
Cellular component morphogenesis (GO:0032989)	545	30	10.29	2.92	6.59E-05
Carbohydrate metabolic process (GO:0005975)	476	24	8.99	2.67	4.35E-03
Cellular component organization (GO:0016043)	1584	77	29.91	2.57	5.18E-12
Organelle organization (GO:0006996)	752	34	14.2	2.39	8.34E-04

Proteins that differed significantly between lean and obese groups were subjected to Panther Pathway over-representation analysis. The expected number of proteins in a pathway is calculated assuming the same proportion of proteins in this pathway in the entire proteome would be present in a given subset of the proteome. Shown are classifications that were significantly and greater than two-fold enriched in the analysis.