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. 2021 Apr 7;11:665379. doi: 10.3389/fcimb.2021.665379

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Copyright © 2021 Song, Zhang, Zhang, Chen, Lin, Han and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The theaflavin inhibits ZIKV infection with low cytotoxicity. (A) Dose dependent inhibition of ZIKV by theaflavin in Huh7 cells. Chloroquine was used as a positive control. (B) qRT-PCR analyses of viral RNA inhibition by theaflavin in Huh7 cells. ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001. Data were shown as the mearn ± SD (N = 3). (C) Cytotoxicity of theaflavin. Huh7 cells were treated with different concentrations of theaflavin (1-128 μM). The cell viability was measured by CCK-8 assay.