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. 2021 Apr 7;12:655739. doi: 10.3389/fimmu.2021.655739

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Copyright © 2021 Lemke, Klement, Schweiger, Schweiger and Spitz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal PTH measurements in a cohort of 41 relapsing-remitting multiple sclerosis patients treated by the corresponding author (DL) with the Coimbra protocol. Black lines indicate the median, blue crosses the mean. At three months follow-up, PTH levels had dropped significantly compared to the baseline measurement (Wilcoxon rank sum test, p<0.001), while there were no significant differences between any of the follow-up measurements. The reduction of PTH concentrations into the middle of the lower third of its laboratory-specific reference range is judged as an indicator for overcoming vitamin D resistance.