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. 2021 Apr 7;9:657456. doi: 10.3389/fcell.2021.657456

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Copyright © 2021 Zhang, Liu, Han, Fan, Wang, Chen, Du, Han, Arnone, Xu, Wei, Mobley and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC exosomes contain DSG1 and deliver DSG1 to the cardiomyocytes of infarcted hearts. (A) mRNA levels of Dsg1 isoforms a/b and c were evaluated in MSCs via qRT-PCR and normalized to GAPDH mRNA levels. (B) The abundance of DSG1 protein in MSCs and MSC exosomes was evaluated via Western blot. (C) ^MetRS*MSC-Exos and ^CTLMSC-Exos were injected into the tail vein of mice 3 days after surgically induced MI. Mice were euthanized 4 h after exosome administration, and heart-tissue sections were click-stained to identify the ANL-labeled ^MetRS*MSC exosomal proteins and immunofluorescently stained for the presence of DSG1 and troponin T (TnT) protein; nuclei were counterstained with DAPI.