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. 2021 Apr 7;12:608491. doi: 10.3389/fneur.2021.608491

Table 1.

Definitions used to diagnose disease progression in MS.

Definition of progression (EDSS worsening from baseline) Time to confirm disease progression Population studied
European Medicines Agency (32) 1.0 point if EDSS ≤ 5.5
0.5 point if EDSS ≥ 6.0		 6 months MS
Kalincik et al. (18) 1.0 point if EDSS ≤ 5.5
0.5 point if EDSS ≥ 6,0		 12 or 24 months PMS (PPMS and SPMS)
Lorscheider et al. (33) 1.0 point if EDSS ≤ 5.5
0.5 point if EDSS ≥ 6.0
FSS ≥ 2		 3 months if basal EDSS ≥ 4.0 SPMS

EDSS, Expanded Disability Status Scale; FSS, Functional Systems Score; PMS, progressive multiple sclerosis; PPMS, primary progressive multiple sclerosis; SPMS, secondary progressive multiple sclerosis.