Table 1.
Assessment of the relationship level of 12 novel loci with PD in the Chinese Han population.
| SNPs/candidate gene | HWE (p-value) | Association test | PD | Control | p | OR (95%CI) | pa | OR (95%CI)a |
|---|---|---|---|---|---|---|---|---|
| rs10748818/GBF1 | 0.73 | Genotypic (GG/GA/AA) | 78/259/190 | 54/194/187 | - | - | ||
| Dominant [(GG + GA)/AA] | 337/190 | 248/187 | 0.028* | 0.748(0.576–0.970) | 0.275 | 0.834(0.601–1.155) | ||
| Recessive [GG/(GA + AA)] | 78/449 | 54/381 | 0.285 | 1.226(0.844–1.780) | 0.857 | 1.030(0.745–1.424) | ||
| Alleles(G/A) | 415/639 | 302/508 | 0.035* | 1.221(1.014–1.472) | ||||
| rs11950533/C5orf24 | 0.99 | Genotypic (CC/CA/AA) | 259/218/50 | 209/186/40 | - | - | ||
| Dominant [(CC + CA)/AA] | 477/50 | 395/40 | 0.877 | 1.035(0.669-1.602) | 0.857 | 1.030 (0.745–1.424) | ||
| Recessive [CC/(CA + AA)] | 259/268 | 209/226 | 0.734 | 1.045(0.811–1.347) | 0.416 | 0.875(0.634–1.208) | ||
| Alleles(C/A) | 736/318 | 604/266 | 0.848 | 1.019(0.839–1.239) | ||||
| rs34025766/LCORL | 0.85 | Genotypic (TT/AT/AA) | 423/96/8 | 336/94/5 | - | - | ||
| Dominant [(TT + AT)/AA] | 519/8 | 430/5 | 0.622 | 0.754(0.245–2.323) | 0.438 | 1.716(0.439–6.710) | ||
| Recessive [TT/(AT + AA)] | 423/104 | 336/99 | 0.253 | 1.198(0.879–1.634) | 0.683 | 0.922(0.625–1.361) | ||
| Alleles(T/A) | 942/112 | 766/104 | 0.358 | 1.142(0.860–1.516) | ||||
| rs55961674/KPNA1 | 0.95 | Genotypic (CC/CT/TT) | 416/103/8 | 333/96/6 | - | - | ||
| Dominant [(CC+CT)/TT] | 519/8 | 429/6 | 0.858 | 0.907(0.312-2.635) | 0.900 | 1.087(0.295–4.004) | ||
| Recessive [CC/(CT+TT)] | 416/111 | 333/102 | 0.375 | 1.148(0.846–1.557) | 0.797 | 0.951(0.646-1.399) | ||
| Alleles(C/T) | 935/119 | 762/108 | 0.447 | 1.114(0.844–1.470) | ||||
| rs61169879/BRIP1 | 0.77 | Genotypic (CC/CT/TT) | 97/271/159 | 84/222/129 | - | - | ||
| Dominant [(CC + CT)/TT] | 368/159 | 306/129 | 0.862 | 0.976(0.739–1.288) | 0.792 | 0.953(0.669–1.359) | ||
| Recessive [CC/(CT + TT)] | 97/430 | 84/351 | 0.721 | 0.943(0.681–1.304) | 0.457 | 1.168(0.775–1.761) | ||
| Alleles(C/T) | 465/589 | 390/480 | 0.755 | 0.972(0.811–1.164) | ||||
| rs666463/DNAH17 | 0.81 | Genotypic (AA/AT/TT) | 498/29/0 | 409/26/0 | - | - | ||
| Dominant [(AA + AT)/TT] | 527/0 | 435/0 | - | - | - | - | ||
| Recessive [AA/(AT + TT)] | 498/29 | 409/26 | 0.753 | 1.092(0.633–1.883) | 0.337 | 1.421(0.693–2.912) | ||
| Alleles(A/T) | 1025/29 | 844/26 | 0.756 | 1.089(0.636–1.863) | ||||
| rs75859381/RPS12 | 0.60 | Genotypic (TT/CT/CC) | 467/59/1 | 395/40/0 | - | - | ||
| Dominant [(TT + CT)/CC] | 526/1 | 435/0 | - | - | 1.000 | - | ||
| Recessive [TT/(CT+CC)] | 467/60 | 395/40 | 0.268 | 0.788(0.517–1.202) | 0.939 | 0.980(0.578–1.660) | ||
| Alleles(T/C) | 993/61 | 830/40 | 0.244 | 0.785(0.521–1.181) | ||||
| rs76116224/KCNS3 | 0.99 | Genotypic (AA/AT/TT) | 523/4/0 | 429/6/0 | - | - | ||
| Dominant [(AA+AT)/TT] | 527/0 | 435/0 | - | - | - | - | ||
| Recessive [AA/(AT + TT)] | 523/4 | 429/6 | 0.532b | 0.541(0.149–1.957) | 0.955 | 0.953(0.180–5.050) | ||
| Alleles(A/T) | 1,050/4 | 864/6 | 0.533b | 1.823(0.513–6.480) | ||||
| rs76949143/GS1-124K5·11 | 0.24 | Genotypic (TT/AT/AA) | 385/135/7 | 333/90/12 | - | - | ||
| Dominant [(TT + AT)/AA] | 520/7 | 423/12 | 0.113 | 2.107(0.822–5.400) | 0.438 | 0.624(0.189–2.054) | ||
| Recessive [TT/(AT + AA)] | 385/142 | 333/102 | 0.215 | 0.830(0.619–1.114) | 0.688 | 1.080(0.740–1.576) | ||
| Alleles(T/A) | 905/149 | 756/114 | 0.511 | 0.916(0.705–1.191) | ||||
| rs77351827/CRLS1 | 1.00 | Genotypic (CC) | 527 | 435 | - | - | ||
| - | - | - | - | - | - | - | ||
| - | - | - | - | - | - | - | ||
| Alleles(C) | 1,054 | 870 | - | - | ||||
| rs7938782/RNF141 | 0.36 | Genotypic (AA/GA/GG) | 373/143/11 | 303/115/17 | - | - | ||
| Dominant [(AA + GA)/GG] | 516/11 | 418/17 | 0.095 | 1.908(0.884–4.117) | 0.120 | 0.469(0.181–1.217) | ||
| Recessive [AA/(GA + GG)] | 373/154 | 303/132 | 0.705 | 1.055(0.799–1.393) | 0.951 | 1.011(0.710–1.440) | ||
| Alleles(A/G) | 889/165 | 721/149 | 0.341 | 0.889(0.697–1.133) | ||||
| rs850738/FAM171A2 | 0.68 | Genotypic (AA/GA/GG) | 184/248/95 | 144/220/71 | - | - | ||
| Dominant [(AA + GA)/GG] | 432/95 | 364/71 | 0.486 | 0.887(0.633–1.243) | 0.186 | 1.337(0.869–2.056) | ||
| Recessive [AA/(GA + GG)] | 184/343 | 144/291 | 0.555 | 1.084(0.829–1.418) | 0.775 | 1.051(0.748–1.477) | ||
| Alleles(A/G) | 616/438 | 508/362 | 0.981 | 1.002(0.835–1.202) |
*
A two-tailed p < 0.05 was considered significant.
a
Adjusted age and sex by logistic regression.
b
Continuous correction for Chi-square test when at least one cell has an expected value of < 5.
PD, Parkinson's disease; SNPs, single nucleotide polymorphisms; HWE, Hardy-Weinberg equilibrium; CI, confidence interval; OR, odds ratio. The bold means the P value < 0.05.