Table 2.
Age-stratified analysis and sex-stratified analysis of 12 loci.
| SNPs (candidate gene) | Genotype, allele | Age onset < 50 years | Age onset ≥ 50 years | Male | Female | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PD | Control | p1 | OR (95%CI)1 | PD | Control | p2 | OR (95%CI)2 | PD | Control | p3 | OR (95%CI)3 | PD | Control | p4 | OR (95%CI)4 | ||
| rs10748818 | GG | 7 | 28 | 0.370 | 71 | 26 | 0.132 | 44 | 27 | 0.126 | 34 | 27 | 0.524 | ||||
| (GBF1) | GA | 16 | 113 | 243 | 81 | 146 | 107 | 131 | 87 | ||||||||
| AA | 23 | 106 | 167 | 81 | 110 | 104 | 80 | 83 | |||||||||
| G | 30 | 169 | 0.766 | 0.931 (0.579–1.495) | 385 | 133 | 0.117 | 1.219(0.952–1.562) | 234 | 161 | 0.080 | 1.251(0.973–1.608) | 181 | 141 | 0.222 | 1.190(0.900–1.572) | |
| A | 62 | 325 | 577 | 243 | 366 | 315 | 273 | 253 | |||||||||
| rs11950533 | CC | 24 | 119 | 0.034* | 235 | 90 | 0.783 | 146 | 108 | 0.704 | 113 | 101 | 0.954 | ||||
| (C5orf24) | CA | 17 | 103 | 201 | 83 | 123 | 106 | 95 | 80 | ||||||||
| AA | 5 | 25 | 45 | 15 | 31 | 24 | 19 | 16 | |||||||||
| C | 65 | 341 | 0.757 | 1.080 (0.663–1.759) | 671 | 263 | 0.944 | 0.991(0.764–1.285) | 415 | 322 | 0.594 | 1.073(0.828–1.390) | 321 | 282 | 0.781 | 0.959(0.712–1.291) | |
| A | 27 | 153 | 291 | 113 | 185 | 154 | 133 | 112 | |||||||||
| rs34025766 | TT | 38 | 188 | - | 385 | 148 | 0.418 | 240 | 190 | - | 183 | 146 | - | ||||
| (LCORL) | AT | 8 | 55 | 88 | 39 | 55 | 46 | 41 | 48 | ||||||||
| AA | 0 | 4 | 8 | 1 | 5 | 2 | 3 | 3 | |||||||||
| T | 84 | 431 | 0.274 | 1.535 (0.709–3.321) | 858 | 335 | 0.961 | 1.010(0.689–1.481) | 535 | 426 | 0.862 | 0.966(0.654–1.427) | 407 | 340 | 0.133 | 1.375(0.907–2.086) | |
| A | 8 | 63 | 104 | 41 | 65 | 50 | 47 | 54 | |||||||||
| rs55961674 | CC | 36 | 190 | - | 380 | 143 | 0.568 | 239 | 185 | - | 177 | 148 | - | ||||
| (KPNA1) | CT | 8 | 55 | 95 | 41 | 57 | 49 | 46 | 47 | ||||||||
| TT | 2 | 2 | 6 | 4 | 4 | 4 | 4 | 2 | |||||||||
| C | 80 | 435 | 0.767 | 0.904 (0.465–1.758) | 855 | 327 | 0.328 | 1.197(0.834–1.718) | 535 | 419 | 0.558 | 1.120(0.767–1.634) | 400 | 343 | 0.643 | 1.101(0.732–1.658) | |
| T | 12 | 59 | 107 | 49 | 65 | 57 | 54 | 51 | |||||||||
| rs61169879 | CC | 9 | 45 | 0.673 | 88 | 39 | 0.439 | 55 | 40 | 0.544 | 42 | 44 | 0.351 | ||||
| (BRIP1) | CT | 22 | 135 | 249 | 87 | 147 | 128 | 124 | 94 | ||||||||
| TT | 15 | 67 | 144 | 62 | 98 | 70 | 61 | 59 | |||||||||
| C | 40 | 225 | 0.714 | 0.920(0.587–1.440) | 425 | 165 | 0.922 | 1.012(0.796–1.287) | 257 | 208 | 0.776 | 0.965(0.757–1.231) | 208 | 182 | 0.912 | 0.985(0.751–1.291) | |
| T | 52 | 269 | 537 | 211 | 343 | 268 | 246 | 212 | |||||||||
| rs666463 | AA | 42 | 229 | 0.978a | 456 | 180 | 0.613 | 284 | 222 | 0.499 | 214 | 187 | 0.768 | ||||
| (DNAH17) | AT | 4 | 18 | 25 | 8 | 16 | 16 | 13 | 10 | ||||||||
| - | - | - | - | - | - | - | - | - | |||||||||
| A | 88 | 476 | 0.978a | 0.832(0.275–2.517) | 937 | 368 | 0.617 | 0.815(0.364–1.823) | 584 | 460 | 0.505 | 1.270(0.628–2.566) | 441 | 384 | 0.771 | 0.883(0.383–2.037) | |
| T | 4 | 18 | 25 | 8 | 16 | 16 | 13 | 10 | |||||||||
| rs75859381 | TT | 41 | 226 | 0.813a | 426 | 169 | - | 267 | 219 | 0.240 | 200 | 176 | - | ||||
| (RPS12) | CT | 5 | 21 | 54 | 19 | 33 | 19 | 26 | 21 | ||||||||
| CC | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |||||||||
| T | 87 | 473 | 0.818a | 0.773(0.284–2.104) | 906 | 357 | 0.583 | 0.861(0.504–1.470) | 567 | 457 | 0.252 | 0.714(0.401–1.273) | 426 | 373 | 0.602 | 0.857(0.478–1.534) | |
| C | 5 | 21 | 56 | 19 | 33 | 19 | 28 | 21 | |||||||||
| rs76116224 | AA | 45 | 242 | 1.000b | 478 | 187 | 1.000a | 296 | 236 | 0.899a | 227 | 193 | 0.098a | ||||
| (KCNS3) | AT | 1 | 5 | 3 | 1 | 4 | 2 | 0 | 4 | ||||||||
| - | - | - | - | - | - | - | - | - | |||||||||
| A | 91 | 489 | 1.000b | 0.930(0.107–8.057) | 959 | 375 | 1.000a | 0.571(0.153–2.133) | 596 | 474 | 0.899a | 0.629(0.115–3.447) | 454 | 390 | 0.099a | 0.462(0.430–0.497) | |
| T | 1 | 5 | 3 | 1 | 4 | 2 | 0 | 4 | |||||||||
| rs76949143 | TT | 38 | 191 | - | 347 | 142 | 0.042* | 217 | 184 | 0.241 | 168 | 149 | - | ||||
| (GS1-124K5·11) | AT | 7 | 51 | 128 | 39 | 78 | 48 | 57 | 42 | ||||||||
| AA | 1 | 5 | 6 | 7 | 5 | 6 | 2 | 6 | |||||||||
| A | 9 | 61 | 140 | 53 | 88 | 60 | 61 | 54 | |||||||||
| rs77351827 | CC | 46 | 247 | - | 481 | 188 | - | - | 300 | 238 | - | - | 227 | 197 | - | - | |
| (CRLS1) | C | 92 | 494 | - | - | 962 | 376 | - | - | 600 | 476 | - | - | 454 | 394 | - | - |
| rs7938782 | AA | 33 | 176 | 0.969 | 340 | 127 | 0.085 | 210 | 162 | 0.327 | 163 | 141 | 0.693 | ||||
| (RNF141) | GA | 12 | 64 | 131 | 51 | 84 | 66 | 59 | 49 | ||||||||
| GG | 1 | 7 | 10 | 10 | 6 | 10 | 5 | 7 | |||||||||
| A | 78 | 416 | 0.890 | 1.045(0.563–1.938) | 811 | 305 | 0.159 | 1.250(0.916–1.707) | 504 | 390 | 0.433 | 0.880(0.638–1.212) | 385 | 331 | 0.751 | 1.062(0.732–1.540) | |
| G | 14 | 78 | 151 | 71 | 96 | 86 | 69 | 63 | |||||||||
| rs850738 | AA | 15 | 74 | 0.843 | 169 | 70 | 0.300 | 102 | 82 | 0.345 | 82 | 62 | 0.587 | ||||
| (FAM171A2) | GA | 24 | 127 | 224 | 93 | 140 | 121 | 108 | 99 | ||||||||
| GG | 7 | 46 | 88 | 25 | 58 | 35 | 37 | 36 | |||||||||
| A | 54 | 275 | 0.591 | 1.132(0.721–1.777) | 562 | 233 | 0.235 | 0.862(0.675–1.101) | 344 | 285 | 0.401 | 0.901(0.705–1.150) | 272 | 223 | 0.329 | 1.146(0.872–1.507) | |
| G | 38 | 219 | 400 | 143 | 256 | 191 | 182 | 171 | |||||||||
*
A two-tailed p < 0.05 was considered significant.
a
Continuous correction for Chi-square test when at least one cell has an expected value of less than 5.
b
Adjusted by Fisher's exact test when at least one cell has an expected value of < 1.
PD, Parkinson's disease; SNPs, single nucleotide polymorphisms; CI, confidence interval; OR, odds ratio. The bold means the P value < 0.05.