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(A) Chemical structure and in vivo metabolic pathway of auranofin. Auranofin is a pro-drug, which is metabolized leading to tetraacetylthioglucose and to the bioactive fragment [Au(PEt3)]+ (AUF). (B) X-ray structure of the NCP displaying the binding of Auranofin (AUF) and RAPTA-T at distal histone sites, separated by ~35 Å.
