Urinary lactulose/rhamnose ratio, a measure of small intestinal permeability, (A; nHealthy=16; nCOPD=18) was higher in Chronic Obstructive Pulmonary Disease (COPD) patients than in healthy controls. Among COPD patients, intestinal permeability was higher in active smokers than in participants who never smoked (B; nnever smoked=4; nformer smoker=8; nactive smoker=6). Urinary 3-O-methyl-glucose (3-OMG) recovery rate, a marker for active carrier-mediated glucose transport, was lower in COPD patients (C: nHealthy=16; nCOPD=17), and decreased to a greater extent in patients who were hospitalized due to an exacerbation in the previous year (D; nno=12; nyes=5). Data are presented as means (SEM).