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. 2021 Apr 7;12:650522. doi: 10.3389/fimmu.2021.650522

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Copyright © 2021 Merino, Sablik, Korevaar, López-Iglesias, Ortiz-Virumbrales, Baan, Lombardo and Hoogduijn

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MP induce angiogenesis in Non- and TNFα Stimulated conditions. (A) Analysis and identification of angiogenic features. (B) Angiogenesis assay images of Non-Stimulated and TNFα stimulated HUVEC under MP treatment. Quantitative image analysis of four angiogenic features (covered area (Blue lines), total tube length, total branching points, and the number of loops) in (C) Non-stimulated HUVEC, and TNFα stimulated HUVEC. The analysis was performed by the company WIMASIS. *p < 0.05 compared with the control (no MP). ^#p < 0.05 respect to Non-Stimulated HUVEC.