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. 2021 Apr 7;12:649752. doi: 10.3389/fgene.2021.649752

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Copyright © 2021 Liu, Zeng, Fan and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transcriptional regulatory network of the five hub genes, miRNAs, and TFs. miRNAs, microRNAs; TFs, transcription factors. A green hexagon node represented the TFs, and a pink diamond node represented regulated miRNA, a light blue circular node represented the hub gene, their interaction was represented by an arrow. The numbers of arrows in the networks demonstrate the contribution of one TFs to miRNAs or one miRNA to the hub genes, and the higher the degree the more central the nodes were within the network.