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. 2021 Apr 7;12:649752. doi: 10.3389/fgene.2021.649752

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Copyright © 2021 Liu, Zeng, Fan and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mRNA level of five hub genes in CRC. Validation of the mRNA expression levels of (A) TIMP1, (B) SPARCL1, (C) MYL9, (D) TPM2, and (E) CNN1 in CRC tissues compared with normal colon tissues from GEPIA database. These five box plots are based on 275 CRC samples (marked in red) and 41 normal samples (marked in gray). *P < 0.01 was considered statistically significant. CRC, colorectal cancer. VEGFC and F8 were filtered out according to the P-value of the mRNA expression levels.