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. 2021 Apr 7;12:649752. doi: 10.3389/fgene.2021.649752

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Copyright © 2021 Liu, Zeng, Fan and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic alteration information and co-expression analysis of the five poor prognostic genes in CRC. (A) A visual summary across a set of CRC (data from colorectal adenocarcinoma, TCGA, Nature 2012) showed the genetic alterations connected with the five hub genes which were altered in 49 (22.7%) of 212 sequenced patients (212 in total). (B) An overview of changes in the five hub genes in the genomics datasets of CRC in TCGA database. Summary for rectal adenocarcinoma: gene altered in 31.48% of 54 cases, mutation 5.56% (3 in 54 cases), amplification 25.93% (14 in 54 cases). Summary for colorectal adenocarcinoma: gene altered in 23.68% of 38 cases, mutation 13.16% (5 in 38 cases), amplification, 5.26% (2 in 38 cases), multiple alterations5.26% (2 in 38 cases). Summary for colon adenocarcinoma: gene altered in 16.67% of 120 cases, mutation, 0.83% (1 in 120 cases), amplification, 15% (18 in 120 cases), deep deletion 0.83% (1 in 120 cases). (C) The co-expression analysis of five hub genes using the STRING online database.