TABLE 1.
Summary of top 10 regulatory biomolecules (TFs and miRNAs) of the five hub genes in CRC identified from TFs-miRNAs-hub genes interactions.
| Number | Symbol | Degree | Feature | References |
| TFs | ||||
| 1 | POLR2A | 14 | Afflicted with cancer | Xu et al., 2019 |
| 2 | SP4 | 10 | Afflicted with CRC | Meng et al., 2020 |
| 3 | TEAD4 | 10 | Afflicted with CRC | Kim et al., 2020 |
| 4 | HMGA1 | 8 | Afflicted with CRC | Yang et al., 2020 |
| 5 | GATA6 | 8 | Afflicted with CRC | Lai et al., 2020 |
| 6 | HSF1 | 7 | Afflicted with CRC | Song et al., 2020 |
| 7 | NR3C1 | 7 | Afflicted with CRC | Sun et al., 2020 |
| 8 | ATF1 | 5 | Afflicted with CRC | Zhao et al., 2020 |
| 9 | PDLIM5 | 5 | Afflicted with CRC | Shi et al., 2020 |
| 10 | ETS1 | 5 | Afflicted with CRC | Xu et al., 2020 |
| 11 | TBP | 5 | Afflicted with CRC | Wei et al., 2020 |
| miRNAs | ||||
| 1 | MIR106A | 18 | Afflicted with CRC | Liu et al., 2020 |
| 2 | MIR424 | 17 | Afflicted with CRC | Di et al., 2020 |
| 3 | MIR497 | 16 | Afflicted with CRC | Bai et al., 2020 |
| 4 | MIR326 | 16 | Afflicted with CRC | Xian et al., 2020 |
| 5 | MIR212 | 15 | Afflicted with CRC | Mou et al., 2019 |
| 6 | MIR193A | 14 | Afflicted with CRC | Hejazi et al., 2020 |
| 7 | MIR214 | 11 | Afflicted with CRC | Liu et al., 2019 |
| 8 | MIR22 | 11 | Afflicted with CRC | Cong et al., 2020 |
| 9 | MIR193B | 10 | Afflicted with cancer | Tian et al., 2020 |
| 10 | MIR182 | 6 | Afflicted with CRC | Lin et al., 2020 |