Fig. 5.

Lithium signaling network. Phosphoproteins altered in rat inner medullary collecting ducts by in vivo lithium administration were clustered according to protein function. Red nodes indicate proteins with phosphosites downregulated by lithium; green nodes indicate proteins with phosphosites that were upregulated by lithium. Nodes with thick borders are protein kinases. Original data were from Trepiccione et al. (2014).