TABLE 2.
Continuation of list from Table 1 of protein phosphosites in MA-10 cells that are increased by a combination of PDE4 and PDE8 inhibitors
| Fold Incr. | Protein Name/Function | Gene Symbol | P04 sequence | |
|---|---|---|---|---|
| 31 | 5.7 | γ-Taxilin–ATF4/Creb2-binding protein | Txlng | _KHS(ph)LEGDEGSDFITK_ |
| 32 | 5.6 | Serine/threonine-protein kinase SIK3 | Sik3/QSK | _RFS(ph)DGAASIQAFK_ |
| 33 | 5.4 | Neuron navigator 1 | Nav1 | _KTS(ph)LDVSNSVEPGFLA |
| 34 | 5.4 | cAMP-regulated phosphoprotein 19 | Arpp19 | DHIPTPQDLPQRKPS(ph)L |
| 35 | 5.1 | Autophagy-related protein 16-1 | Atg16l1 | _RLS(ph)QPAGGLLDSITNI |
| 36 | 5.1 | Protein ETHE1, mitochondrial | Ethe1 | _RLS(ph)QQSASGAPVLLR |
| 37 | 4.9 | Perilipin-1 | Plin1 | _RLS(ph)TQFTAANELACR |
| 38 | 4.7 | ADP-ribosylation factor GTPase-activating prot 1 | Arfgap1 | _RSS(ph)DSWDVWGSGSA |
| 39 | 4.7 | SLAIN motif–containing protein 2 | Slain2 | _LS(ph)LQGHPTDLQTSNV |
| 40 | 4.7 | TBC1 domain family member 10B | Tbc1d10b | _RAS(ph)AGPVPGAVVIAE |
| 41 | 4.6 | A-kinase anchor prot 1, mitochondrial, Dakap1 | Akap1 | _RLS(ph)EEACPGVLSVAPT |
| 42 | 4.5 | RNA polymerase II nuclear localization protein | Slc7a6os | _KTS(ph)DPDVILCNSVELIR |
| 43 | 4.4 | TBC1 domain family member 25 | Tbc1d25; | _RSS(ph)LTTAALPFTQSILS |
| 44 | 4.4 | Vesicle-trafficking protein SEC22b | Sec22b | _NLGS(ph)INTELQDVQR_ |
| 45 | 4.2 | Low-affinity cationic amino acid transporter 2 | Slc7a2 | _NLS(ph)LPFILHEK_ |
| 46 | 4.1 | Golgin subfamily A member 5 | Golga5 | _KS(ph)EPDDELLFDFLNSS |
| 47 | 4.0 | CAP-Gly domain–containing linker protein 2 | Clip2 | _RYS(ph)LIDPASPPELLK_ |
| 48 | 4.0 | Nuclear factor related to κ-B–binding protein | Nfrkb/INO80 | _KGS(ph)LAALYDLAVLKK_ |
| 49 | 3.9 | Pleckstrin homol domain family F m 2 (Phafin2) | Plekhf2 | _RIS(ph)IVESCFGAAGQPL |
| 50 | 3.9 | Cytoskeleton-associated protein 5 | Ckap5 | _KYS(ph)DTDIEPFLK_ |
| 51 | 3.8 | Cytospin-A | Specc1l | _KGS(ph)SGNASEVSVACL |
| 52 | 3.8 | Kinesin-associated protein 3 | Kifap3/Kap3 | _LSEVEQLLYYLQNRRDS(p |
| 53 | 3.8 | GRB14 adapter protein | Grb14 | _RVT(ph)LPAITPIVLQK_ |
| 54 | 3.7 | Rho guanine nucleotide exchange factor 2 | Arhgef2 | _S(ph)LPAGDALYLSFNP |
| 55 | 3.7 | Phospholipase DDHD2 | Ddhd2 | _KNS(ph)VSINRPAM(ox)S |
| 56 | 3.5 | Protein FAM54B | Fam54b | _AS(ph)FETLPNISDLCLK_ |
| 57 | 3.5 | Rho family GTPase activator (Alsin) | Als2 | _RLS(ph)LPGLLSQVSPR_ |
| 58 | 3.5 | Reg of microtubule dynamics prot 3 (PTPIP51) | Fam82a2 | _SHS(ph)LPNSLDYAQASE |
| 59 | 3.5 | Serine/arginine repetitive matrix protein 2 | Srrm2 | _RSS(ph)SELSPEVVEK_ |
| 60 | 3.4 | Low-density lipoprot receptor adapter protein 1 | Ldlrap1/ARH | _NQEGGDVPGTRRDS(ph) |