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Schematic representation of the domain organization of the IRR. L1, the first leucine rich domain; CR, the cysteine rich domain; L2, the second leucine rich domain; Fn(III)-1, the first fibronectin type III domain; Fn(III)-2, the second fibronectin type III domain; Fn(III)-3, the third fibronectin type III domain; C – C-terminus, disulfide bonds are shown as black lines. IRR, insulin receptor-related receptor; JM, junctions membrane domain; TK, the tyrosine kinase catalytic domain.
