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. 2021 Mar 4;12:634176. doi: 10.3389/fphar.2021.634176

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Copyright © 2021 Chen, Yang, Hamdoun, Chung, Lam, Zhang, Guo, Xia, Law and Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PGG on the interaction of Spike-RBD peptide and hACE2 receptor. (A) BLI was used to monitor the binding association of SARS-CoV-2 RBD and hACE2. (B) The binding kinetics and steady-state analysis of the interaction between immobilized RBD and PGG at indicated concentrations. (C) The binding kinetics and steady-state analysis of the interaction between immobilized ACE2 and PGG at indicated concentrations. Representative results were shown from 3 independent experiments.