. 2021 Jan 23;110(6):2501–2507. doi: 10.1016/j.xphs.2021.01.017

Table 3.

Mean (±SD) Comparative Ivermectin (IVM) Concentrations Measured in Nasopharyngeal Tissue, Lung Tissue and Plasma at 6 and 24 h After its Intranasal (N-IVM Spray) (As One and Two Applications) and Oral Administration to Piglets.

	IVM Concentration (ng/g; ng/mL)
	N-IVM spray (one 2 mg dose)	N-IVM spray (two 2 mg doses, 12 h apart)	Oral (one 0.2 mg/kg dose)
	N-IVM spray (one 2 mg dose)	Nasopharyngeal	Oral (one 0.2 mg/kg dose)
6 h	20.7 ± 2.92^a	49.1 ± 18.7^b	23.6 ± 10.8^a
24 h	6.96 ± 6.01^a	10.9 ± 7.58^a	13.0 ± 5.33^a
		Lung tissue
6 h	13.0 ± 4.38^a	34.4 ± 10.2^b	54.7 ± 14.0^c
24 h	5.42 ± 4.69^a	13.0 ± 9.41^a	25.4 ± 10.3^b
		Plasma
6 h	2.13 ± 0.50^a	4.95 ± 2.92^ab	8.60 ± 3.39^b
24 h	1.20 ± 1.04^a	3.37 ± 2.61^b	3.65 ± 0.88^b

Different letters in each row indicate statistically significant differences at P < 0.05. The statistical analyses compares the IVM concentrations measured after N-IVM -spray (one and two doses) and oral treatments for each tissue at the different time sampling points.