. 2021 Jan 23;110(6):2501–2507. doi: 10.1016/j.xphs.2021.01.017

Table 4.

Mean (±SD) Comparative Ratios of Nasopharyngeal to Plasma IVM Concentrations Measured at 6 and 24 h after its Intranasal (N-IVM Spray) (As One and Two Applications) and Oral Administrations to Piglets.

	Ratios of Nasopharyngeal to Plasma Concentrations
	N-IVM spray (one 2 mg dose)	N-IVM spray (two 2 mg doses, 12 h apart)	Oral (one 0.2 mg/kg dose)
6 h	10.3 ± 3.69^a	11.0 ± 4.22^a	2.74 ± 0.60^b
24 h	6.47 ± 3.67^a	4.59 ± 3.02^a	3.64 ± 1.40^a

Different letters in each row indicate statistically significant differences at P < 0.05. The statistical analyses compares the IVM concentrations measured after N-IVM -spray (one and two doses) and oral treatments for each tissue at the different time sampling points.