Table 1.
Treatment Protocols and Costs for 6 Months of Treatment (United States Only)
| Active Ingredient | Brand Names | Dose/Form | Price | Treatment Protocol | 6-Month Drug Cost* |
|---|---|---|---|---|---|
| Tacrolimus | Tacrolimus | 0.5 mg (100 capsules) | $222 | .12 mg/kg/d, 6 mo | $6815 |
| 1 mg (100 capsules) | $445 | ||||
| 5 mg (100 capsules) | $2229 | ||||
| Sirolimus | Sirolimus | 2 mg (100 tablets) | $3149 | 6 mg loading, 2 mg/d, 6 mo | $5731 |
| Rituximab | Rituxan | 100 mg/10 mL (10 mL) | $1042 | 375 mg/m2/wk, 4 wk | $29,184 |
| 500 mg/50 mL (50 mL) | $5212 | ||||
| Ruxolitinib | Jakafi | 5 mg (60 tablets) | $13,856 | 10–20 mg twice daily, 6 mo | $83,136 |
| 10 mg (60 tablets) | $13,856 | ||||
| HCQ | 200 mg (100 tablets) | $408 | 800 mg/d, 6 mo | $2938 | |
| Imatinib | Gleevec | 100 mg (90 tablets) | $10,112 | 100 mg/d, 6 mo | $20,224 |
| Bortezomib | Velcade | 3.5 mg (1 vial) | $1923 | .2 mg/m2/week, 6 months | $46,152 |
| Ibrutinib | Imbruvica | 140 mg (90 capsules) | $13,323 | 420 mg/d, 6 mo | $79,938 |
| ECP | $1348 | † | $41,788 | ||
| Pomalidomide | Pomalyst | 1 mg (21 capsules) | $17,430 | 1–4 mg/d, 21 of 28 d per course, 6 courses | $104,580 |
| 2 mg (21 capsules) | $17,430 | ||||
| 3 mg (21 capsules) | $17,430 | ||||
| 4 mg (21 capsules) | $17,430 | ||||
| Methotrexate | Methotrexate Sodium injection | 25 mg/mL (2 mL) | $8.5 | 7.5 mg/m2/wk, 6 mo | $204 |
HCQ indicates hydroxychloroquine.
*
Cost calculation based on 170 cm height and 70 kg weight and only includes direct costs calculated per described protocol.
†
Three times during week 1, and then twice weekly on consecutive days during weeks 2–12. Responding patients in the ECP group could continue 2 ECP treatments every 4 weeks until week 24.