Table 3.

Organ System–Specific Response Rates

Active Ingredient	Eye Rate (95% CI) Cost per CR + PR	GI Rate (95% CI) Cost per CR + PR	Fasciae/Joint Rate (95% CI) Cost per CR + PR	Liver Rate (95% CI) Cost per CR + PR	Skin Rate (95% CI) Cost per CR + PR	Lung Rate (95% CI) Cost /perCR + PR	Mouth Rate (95% CI) Cost per CR + PR
Tacrolimus	NA	NA	NA	NA	NA	NA	NA
Sirolimus	.59 (.33–83) $9714	.57 (.10–98) $10,054	.33 (.06–79) $17,367	.50 (.23–78) $11,462	.64 (.48–78) $8955	NA	.62 (.39–83) $9244
Rituximab	.28 (.09–52) $104,229	.33 (.01–78) $88,436	.77 (.47–98) $37,901	.44 (.19–70) $66,327	.61 (.51–71) $47,843	NA	.52 (.22–81) $56,123
Ruxolitinib	NA	NA	NA	NA	NA	NA	NA
HCQ	.00 (.00–43)	.00 (.00–49)	.00 (.00–66)	.18 (.05–48) $16,322	.25 (.09–53) $11,752	NA	.22 (.06–55) $13,355
Imatinib	.58 (.33–81) $34,869	.72 (.47–92) $28,089	.55 (.30–79) $36,771	.30 (.00–74) $67,413	.56 (.29–81) $36,114	.33 (.14–61) $ 61,285	.30 (.07–58) $67,413
Bortezomib	.67 (.30–90) $68,884	.50 (.09–91) $92,304	.50 (.09–91) $92,304	.00 (.00–79)	.50 (022–78) $92,304	NA	.56 (.27–81) $82,414
Ibrutinib	NA	NA	NA	NA	NA	NA	NA
ECP	.65 (.44–84) $64,289	.68 (.20, 1.00) $61,453	.52 (.31–72) $80,362	.63 (.34–87) $66,330	.65 (.51–78) $64,289	.67 (.35–94) $ 62,370	.69 (.51–84) $60,562
Pomalidomide	.33 (.10–70) $316,909	.50 (.15–85) $209,160	.17 (.03–56) $615,176	.00 (.00–79)	.63 (.31–86) $166,000	NA	.29 (.08–64) $360,621
Methotrexate	.56 (.11, 0,97) $364	.80 (.38–96) $255	.33 (.10–70) $618	.67 (.40–90) $304	.78 (.30, 1.00) $262	NA	.40 (.06–79) $510

NA indicates not available; GI, gastrointestinal.

^*Cost calculation based on 170 cm height and 70 kg weight and only includes direct costs calculated per described protocol.