Figure 3. Change in Tumor-Lesion Size and Duration of Responses with 5F9 and Rituximab.
Panel A shows a waterfall plot of the best overall change in the size of tumor target lesions among patients with diffuse large B-cell lymphoma (DLBCL; indicated by an asterisk) or follicular lymphoma, according to the maintenance dose received. Plots of the percentage changes in the tumor burden of target lesions are shown graphically. All the tumor lesions were measured in centimeters. A target lesion size of “too small to measure” was imputed as 0.5 cm2, and “not visible” as 0 cm2. One patient could not be evaluated because of discontinuation of the study before the first protocol-specified response assessment. Thresholds regarding progressive disease and partial response according to the Lugano criteria18 are indicated by dashed lines. Per the Lugano criteria, patients met the criteria for response by either a decrease in the tumor lesion size as assessed by computed tomography (data shown) or a decrease in metabolic activity as assessed by positron-emission tomography (data not shown). Panel B shows spider plots of data from patients with DLBCL, according to response to treatment, and Panel C shows data from patients with follicular lymphoma; the median duration of response and median follow-up are also shown. A plus sign indicates that the response was ongoing at the time of data cutoff. The dashed line at 0 indicates no change from baseline.