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. 2021 Apr 6;10(4):e24731. doi: 10.2196/24731

Table 1.

General information at each phase of data collection.

Study component Phase 1 (N=308) Phase 2 (n=185) Phase 3 (n=148)
Design Prospective Prospective Cross-sectional and retrospective
Study visits Routine clinical evaluation every 3 months; virological data collected every 6 months; fibrosis or serological data collected every 12 months Routine clinical evaluation and data collection every 6 and 12 months for participants with F3/F4 and F0/F1/F2 fibrosis, respectivelya Cross-sectional visit including comprehensive clinical evaluation on viral hepatitis and liver fibrosis; retrospective data collected since last visit in phase 1 or 2
Inclusion period 2002-2003 2007-2008 2016-2018
Follow-up period 2002-2006 2007-2011 N/Ab
Number of patients completing follow-up, n (%) 275 (89.3) 163 (88.1) 147 (99.3)
Number of deaths

Total 3 8 31

Observed 3 6c 26c

Updatedd 0 2 5
Follow-up time (years), median (IQR) 3.0 (3.0-3.2) 7.3 (3.1-8.0)e 9.2 (3.4-14.6)e

aIn accordance with the European AIDS Clinical Society guidelines for the clinical management and treatment of chronic hepatitis B and C coinfection in adults with HIV [18].

bN/A: not applicable.

cIncludes deaths during time gaps in between phases.

dUsing linked data from a national death certificate registry (CépiDC).

eCumulated over previous phases—this statistic applies to all 308 patients regardless of the phase in which they discontinued participation.