Table 2.

Substrate Scope for the CuH-Catalyzed Hydrocarboxylation of Allenes^a

^aConditions: 0.50 mmol 2d (1.0 equiv), 1 (1.2 equiv), copper(II) acetate (5.0 mol %), L2 (5.5 mol %), dimethoxy(methyl)silane (3.0 equiv) in THF (0.5 M); workup A: NH₄F/MeOH workup followed by hydrolysis using TFA; workup B: NH₄F/MeOH workup; yields refer to average isolated yields of two runs; see the Supporting Information for details.

^bReaction was carried out at 40 °C.

^cReaction was carried out at 30 °C.

^dL3 was used as the ligand instead.

^e1 (1.1 equiv) was used. ^fReaction was carried out at 0 °C in 1,2-dimethoxyethane (DME, 1.0 mL).