TABLE 3.
Neonatal characteristics in external evaluation dataset.
| Center | SH | SZ | Total dataset | |||
|---|---|---|---|---|---|---|
| Variable | Mean ± SD | Median (range) | Mean ± SD | Median (range) | Mean ± SD | Median (range) |
| No. of patients (male/female) | 80 (54/26) | — | 91 (54/37) | — | 171 (108/63) | — |
| No. of serum concentration measured | 165 | — | 154 | — | 319 | — |
| Weight (kg) | 2.87 ± 0.89 | 2.74 (1.4–5.6) | 2.19 ± 0.90 | 1.9 (0.81–4.71) | 2.55 ± 2.42 | 2.42 (0.81–5.6) |
| Birth weight (g) | 2,393 ± 968 | 2,410 (850–4,000) | 2006.48 ± 871.88 | 1700 (740–3,700) | 2,186 ± 907 | 1,000 (740–4,000) |
| Height (cm) | 46.8 ± 4.72 | 47 (37–65) | 43.26 ± 5.48 | 42 (26–53) | 44.7 ± 5.27 | 45 (26–65) |
| Postnatal age, PNA (days) | 32.3 ± 24.1 | 24 (4–126) | 18.46 ± 10.28 | 17 (4–50) | 24.7 ± 17.3 | 20 (4–126) |
| Gestational weeks, GA (week) | 34.7 ± 4.31 | 34 (25.7–41.1) | 33.32 ± 4.11 | 32.6 (25.7–41.3) | 34.1 ± 4.08 | 33.1 (25.7–41.3) |
| Postmenstrual age, PMA (week) | 39.4 ± 3.60 | 40.0 (29–47.1) | 35.95 ± 3.96 | 35.02 (28.27–43.99) | 37.6 ± 4.04 | 37.8 (28.27–47.1) |
| Serum creatinine a (μmol/L) | 23.2 ± 10.4 | 28.3 (5.85–61.6) | 31.85 ± 9.70 | 32.20 (13.05–54.2) | 26.4 ± 10.4 | 26.4 (13.05–61.6) |
| Creatinine clearance (ml/min/1.73m2) | 52.3 ± 17.5 | 51.4 (21.8–92.5) | 36.21 ± 14.88 | 32.09 (17.63–87.63) | 41.2 ± 17.9 | 45.4 (17.63–92.5) |
| Blood urea nitrogen, BUN (mmol/L) | 4.96 ± 3.89 | 4.10 (0.40–28.5) | 4.01 ± 2.89 | 3.17 (0.46–15.87) | 4.1 ± 3.0 | 3.49 (0.46–28.5) |
| First dosage (mg) | 45.0 ± 16.4 | 42 (20–105) | 32.20 ± 16.32 | 25 (8–85) | 34.3 ± 17.1 | 30 (8–105) |
| Trough concentration (mg/L) | 11.2 ± 7.92 | 9.15 (3.14–42.9) | 12.17 ± 6.78 | 10.48 (3.32–32.23) | 11.7 ± 7.37 | 9.94 (3.32–42.9) |
| Peak concentration (mg/L) | 22.3 ± 11.0 | 20.3 (4.09–51.9) | — | — | 22.3 ± 11.0 | 20.3 (4.09–51.9) |
| Albumin, ALB (g/L) | 32.4 ± 5.49 | 32.0 (21.6–46.8) | 30.40 ± 4.85 | 30.49 (13.39–44.09) | 31.2 ± 4.80 | 31.4 (13.39–46.8) |
a
Schwartz Equation.