Table 1.
Characteristics of the study cohort
| Control (N=30) | ACS (N=67) | ACS-statins (N=36) | P value | |
|---|---|---|---|---|
| Age* | 54.87±7.65 | 62.03±10.95 | 62.33±9.52 | 0.003bc |
| Male* | 12 (40.0) | 48 (71.6) | 29 (80.6) | <0.001bc |
| SBP* | 117.80±9.56 | 131.64±18.94 | 125.75±14.94 | 0.001bc |
| BMI* | 24.35±2.82 | 26.47±3.23 | 26.52±3.09 | 0.005bc |
| No. sv§ | ||||
| NA | NA | 2 (3.0) | 3 (8.3) | NA |
| 1 | NA | 22 (32.8) | 7 (19.4) | NA |
| 2 | NA | 17 (25.4) | 6 (16.7) | NA |
| 3 | NA | 26 (38.8) | 20 (55.6) | NA |
| Type of ACS§ | ||||
| UA | NA | 48 (71.6) | 27 (75.0) | NA |
| NSTEMI | NA | 12 (17.9) | 3 (8.3) | NA |
| STEMI | NA | 7 (10.5) | 6 (16.7) | NA |
| Gensini# | NA | 32.5 (18,55) | 33 (22,50) | ns |
| Medications | ||||
| HTN drug§ | 4 (13.3) | 39 (58.2) | 24 (66.7) | <0.001bc |
| OAD§ | 1 (3.3) | 17 (25.4) | 16 (44.4) | 0.001abc |
| Smoke history§ | 4 (13.3) | 39 (58.2) | 20 (55.6) | <0.001bc |
| Drink history§ | 3 (10.0) | 35 (52.2) | 19 (52.8) | <0.001bc |
| HTN§ | 6 (20.0) | 44 (65.7) | 23 (63.9) | <0.001bc |
| T2DM§ | 1 (3.3) | 17 (25.4) | 16 (44.4) | 0.001abc |
| HLP§ | 8 (26.7) | 31 (46.3) | 30 (83.3) | <0.001ac |
| OMI§ | 0 (0.0) | 13 (19.4) | 2 (5.6) | 0.009b |
| Laboratory data | ||||
| TC* | 4.81±0.87 | 4.02±0.88 | 3.81±1.30 | <0.001bc |
| TG* | 1.54±0.95 | 1.64±0.70 | 1.65±1.01 | ns |
| HDL-C* | 1.22±0.35 | 0.97±0.23 | 0.92±0.15 | <0.001bc |
| LDL-C* | 2.82±0.75 | 2.35±0.76 | 2.14±1.04 | 0.005bc |
| hsCRP† | 0.66 (0.37,1.21) | 2.13 (0.87,4.11) | 2.03 (0.64,3.43) | 0.001bc |
| cTnI† | 0.00 (0.00,0.00) | 0.01 (0.00,0.05) | 0.01 (0.00,0.04) | <0.001bc |
*mean ± SD, §n (%), #median (IQR).
For the difference comparison of clinical characteristics among the three groups, one-way analysis of variance (ANOVA) was employed in cases of continuous normally distributed data. The Bonferroni test was applied for post hoc comparisons in cases of equal variance, and the Tamhane test was applied in cases of unequal variance. The Kruskal-Wallis H-test was applied for continuous data that were not normally distributed among the three groups, and the Mann-Whitney U test was applied for this kind of data between two groups. Categorical variables were compared by the χ2 test or Fisher's exact test. NA: not available. SBP: systolic blood pressure. BMI: body mass index. No.sv: number of stenosed vessels. HTN: hypertension. OAD: oral anti-diabetic drugs. T2DM: type 2 diabetes mellitus. HLP: hyperlipidemia. OMI: old myocardial infarction. TC: total cholesterol. TG: triacylglycerol. HDL-C: high-density lipoprotein cholesterol. LDL-C: low-density lipoprotein cholesterol. hsCRP: high sensitivity C-reactive protein. cTnI: cardiac troponin I. a: ACS-statins vs ACS. b: ACS versus Control. c: ACS-statins vs Control.