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. 2021 Mar 31;11(12):5759–5777. doi: 10.7150/thno.57659

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HOXB5 is essential for FGF19/15-mediated HCC metastasis. (A) Western blotting showed the HOXB5 and FGF19 expression in different group (left). Transwell showed the ability of migration and invasion of PLC/PRF/5 cells in different group (right). (B) Western blotting showed FGF15 and HOXB5 expression in different group. (C-G) HOXB5 promoted HCC metastasis through upregulating CXCL1. (C-D) The C57BL/6 mice were implanted with the indicated cells in the liver. Bioluminescent images, growth rate and metastatic rate were shown. (E) Survival curve was shown in different groups. (F) Lung metastatic nodules was counted. (G) HE staining showed lung metastatic nodules in different groups. * P < 0.05.