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. 2021 Mar 31;11(12):5813–5830. doi: 10.7150/thno.58731

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M1-EVs promote embryo abortion by transferring miR-146a-5p and miR-146b-5p.M1-EVs were injected into female C57BL/6 mice via the tail vein on days 0.5 (the day of vaginal plug detection), 3.5, and 7.5. (A-D) Expression levels of miR-146a-5p and miR-146b-5p in the peripheral blood, spleen, placenta, and uterus measured by RT-PCR on day 11.5. (E) Embryo absorption rate in the M1-EVs and control groups. (F) Expression level of TRAF6 protein in the placenta measured by western blotting. (G,H) Distribution of TRAF6 in the placenta and uterus detected using IHC. Scale bars: 200 ×, 50 nm; 400 ×, 20 nm. Error bars, SD.