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. 2021 Mar 31;11(12):5813–5830. doi: 10.7150/thno.58731

Figure 8.

Figure 8

miR-146a-5p and miR-146b-5p are upregulated in placental villous tissues from patients with RSA. (A,B) Expression levels of miR-146a-5p and miR-146b-5p measured by RT-PCR in the placental villous tissues of patients with RSA (n = 34) and control patients (n = 20). (C,D) Expression levels of TRAF6 protein and mRNA in the placental villous tissues measured by western blotting and RT-PCR, respectively. (E) Negative correlation between TRAF6 and miR-146a-5p expression levels in the placental villous tissues of patients with RSA (n = 34; r = -0.547, P = 0.001). (F) Negative correlation between TRAF6 and miR-146b-5p expression levels in the placental villous tissues of patients with RSA (n = 34; r = -0.527, P = 0.002). (G) Distributions of miR-146a-5p and TRAF6 in the placental villous tissues of patients with RSA detected by ISH and IHC, respectively. (H) Negative correlation between TRAF6 and miR-146a-5p expression levels in the placental villous tissues of patients with RSA (n = 34; r = -0.522, P = 0.003). (I) Distributions of miR-146b-5p and TRAF6 in the placental villous tissues of patients with RSA detected by ISH and IHC, respectively. (J) Negative correlation between TRAF6 and miR-146b-5p expression levels in the placental villous tissues of patients with RSA (n = 34; r = -0.508, P = 0.002). Scale bars: 200 ×, 50 nm; 400 ×, 20 nm. Error bars, SD.