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Schematic illustration of M1-Mφ-derived miR-146a-5p and miR-146b-5p inhibition of trophoblast EMT, migration, and invasion in RSA. Extracellular vesicles derived from M1-Mφ suppress EMT, migration, and invasion of trophoblasts by transporting miR-146a-5p and miR-146b-5p to directly inhibit TRAF6 expression at the post-transcriptional level, thereby participating in the pathogenesis of RSA.
