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. 2021 Mar 31;11(12):5700–5712. doi: 10.7150/thno.55163

Figure 3.

Figure 3

IDA-SDDS show higher efficiency of content release and tumor uptake in vivo than DXR-SDDS under HT. (A) Schematic illustration of hyperthermia treatment and collection of blood samples in mice. (B, C) Plasma drug concentration comparisons before and after 1 h local hyperthermia (HT) (42 °C) or normothermia (NT) (37 °C) in BFS-1 tumor bearing mice treated with low dose (A) or high dose (B) SDDS (n = 3 mice per group). Complete release is observed with IDA-SDDS plus HT. (D) Under HT, tumors take up released IDA more efficiently and maintained a higher drug level during 48 h post treatment compared to DXR (n ≥ 3 mice per group, Nonparametric Mann-Whitney test: *p < 0.03). (E) The ratio of tumor drug concentration between IDA and DXR calculated from (D) gradually increases within 48 h after treatment, confirming longer retention of IDA in cell after uptake. Data are represented as mean ± SEM.