Table 3.
Proportion and odds ratios of response, remission and subjective memory worsening
| N included | Response/remission/memory worsening, % | Crude odds ratio (95% CI) | P-value | Adjusted odds ratio (95% CI) | P-value | |
|---|---|---|---|---|---|---|
| Response, CGI-I | ||||||
| Low-dose interval | 3140 | 75.7% | 1.27 (1.11–1.45) | <0.001 | 1.22 (1.07–1.40) | 0.004 |
| Medium-dose interval | 2266 | 74.8% | 1.21 (1.05–1.39) | 0.008 | 1.15 (1.00–1.33) | 0.056 |
| High-dose interval | 1805 | 71.1% | Reference | Reference | Reference | Reference |
| Distinct response, CGI-I | ||||||
| Low-dose interval | 3140 | 32.7% | 1.60 (1.40–1.83) | <0.001 | 1.51 (1.32–1.73) | <0.001 |
| Medium-dose interval | 2266 | 29.4% | 1.37 (1.19–1.58) | <0.001 | 1.32 (1.14–1.53) | <0.001 |
| High-dose interval | 1805 | 23.3% | Reference | Reference | Reference | Reference |
| Remission, CGI-S | ||||||
| Low-dose interval | 2950 | 23.0% | 1.48 (1.27–1.72) | <0.001 | 1.37 (1.17–1.60) | <0.001 |
| Medium-dose interval | 2134 | 21.6% | 1.36 (1.16–1.60) | <0.001 | 1.30 (1.10–1.54) | 0.002 |
| High-dose interval | 1716 | 16.8% | Reference | Reference | Reference | Reference |
| Response, MADRS-S | ||||||
| Low-dose interval | 1470 | 65.4% | 1.39 (1.17–1.65) | <0.001 | 1.31 (1.09–1.56) | 0.004 |
| Medium-dose interval | 1026 | 60.7% | 1.13 (0.94–1.36) | 0.180 | 1.06 (0.87–1.28) | 0.556 |
| High-dose interval | 889 | 57.7% | Reference | Reference | Reference | Reference |
| Remission, MADRS-S | ||||||
| Low-dose interval | 1801 | 43.9% | 1.45 (1.24–1.70) | <0.001 | 1.31 (1.11–1.55) | 0.002 |
| Medium-dose interval | 1210 | 39.7% | 1.22 (1.03–1.45) | 0.023 | 1.13 (0.94–1.36) | 0.18 |
| High-dose interval | 1031 | 35.0% | Reference | Reference | Reference | Reference |
| Subjective memory worsening | ||||||
| Low-dose interval | 1923 | 21.6% | 1.34 (1.11–1.62) | 0.002 | 1.32 (1.09–1.60) | 0.004 |
| Medium-dose interval | 1398 | 17.0% | 1.00 (0.81–1.22) | 0.971 | 0.99 (0.80–1.22) | 0.893 |
| High-dose interval | 1176 | 17.0% | Reference | .. | Reference | .. |
For each outcome, the table shows the number of included patients (if patients had missing data on the outcome they were excluded from the logistic regression models). The proportion of each outcome. Crude odds ratios and their 95% confidence intervals were calculated by correlating the age and gender-adjusted dose intervals and the outcomes without any further variables. A regression model adjusted for age, gender, number of treatments, psychiatric comorbidity and psychiatric pharmacotherapy was used to calculate adjusted odds ratios and their 95% confidence intervals. P-values are shown for both crude and adjusted odds ratios separately. CGI-S, Clinical Global Impression – Severity Scale; CGI-I, Clinical Global Impression – Improvement Scale; MADRS-S, Montgomery–Åsberg Depression Rating Scale, self-rated version.