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. 2021 Feb 5;7(2):e44. doi: 10.1192/bjo.2020.145

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© The Author(s) 2021

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Variances in depression liability explained by polygenic risk score (PRS).

Excluding (excl.) 23andMe, PRS calculated using summary statistics from the subset of the Psychiatric Genomics Consortium (PGC) major depressive disorder (MDD) sample (excluding UK Biobank and 23andMe). Including (incl.) 23andMe, PRS calculated using summary statistics from the full PGC MDD sample (excluding UK Biobank). Results are shown for the optimal P_T for each test of association. R² estimates were transformed to the liability scale using a population prevalence of 15% across all UK Biobank phenotypes. Observed P-values are shown above each bar. MHQ, Mental Health Questionnaire