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Pharmacokinetic Parameters of Intravenous Fenretinide (4-HPR)
| 905 mg/m2/d (n=3) | 1131 mg/m2/d (n=3) | |||
|---|---|---|---|---|
| Median | Range | Median | Range | |
| V (L) | 168.5 | 74.4–255.9 | 193.1 | 122.5–420.5 |
| CL (L/h) | 6.1 | 4.3–11.0 | 8.9 | 5.2–10.2 |
| t1/2 (h) | 16.2 | 11.9–19.0 | 16.3 | 15.0–28.5 |
| AUC0–192 (μg·h/mL) | 1279 | 897–1532 | 1297 | 809–1859 |
| Cmax (μg/mL) | 12.2 | 8.1–14.5 | 12.3 | 7.8–18.8 |
| Css (μg/mL) | 10.5 | 7.2–12.1 | 10.4 | 7.0–15.0 |
