Table 2.
Associations of FGFR2 and MGAT5 genetic variants with COPD risk
| Gene | SNP | Model | Genotype | Frequency | Without adjustment | With adjustment | |||
|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | pa | OR (95% CI) | pb | ||||
| FGFR2 | rs2420915 | Codominant | GG | 0.326 | 0.446 | 1.00 | 1.00 | ||
| AA | 0.153 | 0.115 | 1.83 (1.11–3.02) | 0.018 | 1.85 (1.12–3.07) | 0.016 | |||
| AG | 0.521 | 0.439 | 1.62 (1.15–2.28) | 0.006 | 1.62 (1.15–2.28) | 0.006 | |||
| Dominant | GG | 0.326 | 0.446 | 1.00 | 1.00 | ||||
| AA + AG | 0.674 | 0.554 | 1.66 (1.20–2.30) | 0.002 | 1.67 (1.20–2.31) | 0.002 | |||
| Recessive | AG + GG | 0.847 | 0.885 | 1.00 | 1.00 | ||||
| AA | 0.153 | 0.115 | 1.40 (0.88–2.22) | 0.156 | 1.42 (0.89–2.26) | 0.139 | |||
| Additive | – | – | – | 1.42 (1.12–1.80) | 0.003 | 1.43 (1.13–1.81) | 0.003 | ||
| FGFR2 | rs1907240 | Codominant | AA | 0.348 | 0.373 | 1.00 | 1.00 | ||
| GG | 0.195 | 0.146 | 1.42 (0.90–2.26) | 0.135 | 1.43 (0.90–2.27) | 0.133 | |||
| GA | 0.457 | 0.481 | 1.02 (0.72–1.44) | 0.926 | 1.02 (0.72–1.45) | 0.901 | |||
| Dominant | AA | 0.348 | 0.373 | 1.00 | 1.00 | ||||
| GG + GA | 0.652 | 0.627 | 1.11 (0.80–1.54) | 0.525 | 1.12 (0.81–1.55) | 0.507 | |||
| Recessive | GA + AA | 0.805 | 0.854 | 1.00 | 1.00 | ||||
| GG | 0.195 | 0.146 | 1.41 (0.93–2.15) | 0.108 | 1.41 (0.93–2.15) | 0.109 | |||
| Additive | – | – | – | 1.16 (0.93–1.45) | 0.196 | 1.16 (0.93–1.45) | 0.190 | ||
| FGFR2 | rs2257129 | Codominant | CC | 0.342 | 0.370 | 1.00 | 1.00 | ||
| TT | 0.169 | 0.145 | 1.27 (0.79–2.04) | 0.332 | 1.27 (0.79–2.05) | 0.329 | |||
| TC | 0.489 | 0.486 | 1.09 (0.77–1.54) | 0.629 | 1.10 (0.77–1.55) | 0.607 | |||
| Dominant | CC | 0.342 | 0.370 | 1.00 | 1.00 | ||||
| TT + TC | 0.658 | 0.630 | 1.13 (0.81–1.57) | 0.466 | 1.14 (0.82–1.58) | 0.450 | |||
| Recessive | TC + CC | 0.831 | 0.855 | 1.00 | 1.00 | ||||
| TT | 0.169 | 0.145 | 1.21 (0.78–1.86) | 0.398 | 1.20 (0.78–1.86) | 0.402 | |||
| Additive | – | 1.12 (0.89–1.40) | 0.340 | 1.12 (0.89–1.41) | 0.333 | ||||
| MGAT5 | rs6430491 | Codominant | GG | 0.400 | 0.318 | 1.00 | 1.00 | ||
| AA | 0.102 | 0.194 | 0.42 (0.25–0.69) | 0.0006 | 0.41 (0.25–0.68) | 0.0005 | |||
| AG | 0.498 | 0.487 | 0.81 (0.58–1.15) | 0.242 | 0.81 (0.58–1.15) | 0.240 | |||
| Dominant | GG | 0.400 | 0.318 | 1.00 | 1.00 | ||||
| AA + AG | 0.600 | 0.682 | 0.70 (0.51–0.97) | 0.033 | 0.70 (0.50–0.97) | 0.033 | |||
| Recessive | AG + GG | 0.898 | 0.806 | 1.00 | 1.00 | ||||
| AA | 0.102 | 0.194 | 0.47 (0.30–0.74) | 0.0012 | 0.47 (0.29–0.74) | 0.0012 | |||
| Additive | – | – | – | 0.68 (0.54–0.86) | 0.0014 | 0.68 (0.54–0.86) | 0.0013 | ||
| MGAT5 | rs2593704 | Codominant | CC | 0.619 | 0.529 | 1.00 | 1.00 | ||
| GG | 0.054 | 0.077 | 0.60 (0.31–1.15) | 0.121 | 0.61 (0.31–1.17) | 0.136 | |||
| GC | 0.327 | 0.394 | 0.71 (0.51–0.99) | 0.045 | 0.72 (0.51–1.01) | 0.057 | |||
| Dominant | CC | 0.619 | 0.529 | 1.00 | 1.00 | ||||
| GG + GC | 0.381 | 0.471 | 0.69 (0.50–0.95) | 0.023 | 0.70 (0.51–0.97) | 0.031 | |||
| Recessive | GC + CC | 0.946 | 0.923 | 1.00 | 1.00 | ||||
| GG | 0.054 | 0.077 | 0.68 (0.36–1.29) | 0.239 | 0.69 (0.36–1.31) | 0.258 | |||
| Additive | – | – | – | 0.74 (0.57–0.96) | 0.022 | 0.75 (0.58–0.97) | 0.029 | ||
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
pa values were calculated by logistic regression analysis with the comparison between COPD patients and healthy controls
pb values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)