Table 3.
The relationship of FGFR2 and MGAT5 SNPs with COPD risk stratified by age and gender
| Age | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene SNP | Model | Genotype | > 70 years | ≤ 70 years | ||||||
| Frequency in case | Frequency in control | OR (95% CI) | p | Frequency in case | Frequency in control | OR(95% CI) | p | |||
|
FGFR rs2420915 |
Allele | G | 0.581 | 0.658 | 1.00 | 0.594 | 0.675 | 1.00 | ||
| A | 0.419 | 0.342 | 1.39 (1.03–1.88) | 0.032 | 0.406 | 0.325 | 1.42 (0.99–2.02) | 0.054 | ||
| Codominant | GG | 0.301 | 0.429 | 1.00 | 0.362 | 0.467 | 1.00 | |||
| AA | 0.140 | 0.113 | 2.09 (1.03–4.25) | 0.043 | 0.173 | 0.117 | 1.79 (0.83–3.86) | 0.137 | ||
| AG | 0.559 | 0.458 | 1.87 (1.17–3.01) | 0.010 | 0.465 | 0.416 | 1.41 (0.83–2.42) | 0.207 | ||
| Dominant | GG | 0.301 | 0.429 | 1.00 | 0.362 | 0.467 | 1.00 | |||
| AA + AG | 0.699 | 0.571 | 1.91 (1.21–3.02) | 0.005 | 0.638 | 0.533 | 1.50 (0.90–2.48) | 0.119 | ||
| Recessive | AG + GG | 0.860 | 0.887 | 1.00 | 0.827 | 0.883 | 1.00 | |||
| AA | 0.140 | 0.113 | 1.43 (0.75–2.74) | 0.278 | 0.173 | 0.117 | 1.50 (0.73–3.06) | 0.269 | ||
| Additive | – | – | – | 1.55 (1.11–2.17) | 0.010 | – | – | 1.36 (0.95–1.95) | 0.097 | |
|
MGAT5 rs2593704 |
Allele | C | 0.803 | 0.766 | 1.00 | 0.752 | 0.675 | 1.00 | ||
| G | 0.197 | 0.234 | 0.80 (0.56–1.14) | 0.223 | 0.248 | 0.325 | 0.69 (0.47–1.00) | 0.052 | ||
| Codominant | CC | 0.654 | 0.601 | 1.00 | 0.567 | 0.438 | 1.00 | |||
| GG | 0.048 | 0.069 | 0.72 (0.28–1.83) | 0.490 | 0.063 | 0.088 | 0.53 (0.20–1.43) | 0.212 | ||
| GC | 0.298 | 0.330 | 0.88 (0.55–1.41) | 0.599 | 0.370 | 0.474 | 0.60 (0.36–1.01) | 0.054 | ||
| Dominant | CC | 0.654 | 0.601 | 1.00 | 0.567 | 0.438 | 1.00 | |||
| GG + GC | 0.346 | 0.399 | 0.85 (0.55–1.33) | 0.487 | 0.433 | 0.562 | 0.59 (0.36–0.97) | 0.038 | ||
| Recessive | GC + CC | 0.952 | 0.931 | 1.00 | 0.937 | 0.912 | 1.00 | |||
| GG | 0.048 | 0.069 | 0.75 (0.30–1.89) | 0.541 | 0.063 | 0.088 | 0.68 (0.26–1.76) | 0.423 | ||
| Additive | – | – | – | 0.86 (0.60–1.24) | 0.425 | – | – | 0.67 (0.44–0.99) | 0.047 | |
| Gender | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene SNP | Model | Genotype | Male | Female | ||||||
| Frequency in case | Frequency in control | OR (95% CI) | p | Frequency in case | Frequency in control | OR (95% CI) | p | |||
| FGFR | Allele | G | 0.601 | 0.667 | 1.00 | 0.540 | 0.662 | 1.00 | ||
| rs2420915 | A | 0.399 | 0.333 | 1.33 (1.02–1.73) | 0.035 | 0.460 | 0.338 | 1.67 (1.05–2.66) | 0.029 | |
| Codominant | GG | 0.344 | 0.451 | 1.00 | 0.267 | 0.429 | 1.00 | |||
| AA | 0.143 | 0.119 | 1.63 (0.91–2.90) | 0.101 | 0.187 | 0.104 | 2.91 (1.04–8.17) | 0.043 | ||
| AG | 0.513 | 0.430 | 1.55 (1.05–2.30) | 0.027 | 0.546 | 0.467 | 1.90 (0.93–3.88) | 0.080 | ||
| Dominant | GG | 0.344 | 0.451 | 1.00 | 0.267 | 0.429 | 1.00 | |||
| AA + AG | 0.656 | 0.549 | 1.57 (1.08–2.27) | 0.017 | 0.733 | 0.571 | 2.08 (1.05–4.13) | 0.036 | ||
| Recessive | AG + GG | 0.857 | 0.881 | 1.00 | 0.813 | 0.896 | 1.00 | |||
| AA | 0.143 | 0.119 | 1.28 (0.75–2.19) | 0.370 | 0.187 | 0.104 | 1.98 (0.78–5.04) | 0.152 | ||
| Additive | – | – | – | 1.35 (1.03–1.77) | 0.030 | – | – | 1.75 (1.07–2.86) | 0.026 | |
| MGAT5 | Allele | C | 0.795 | 0.714 | 0.64 (0.48–0.87) | 0.004 | 0.743 | 0.764 | 1.11 (0.66–1.89) | 0.687 |
| rs2593704 | G | 0.205 | 0.286 | 1.00 | 0.257 | 0.236 | 1.00 | |||
| Codominant | CC | 0.645 | 0.508 | 0.54 (0.26–1.15) | 0.110 | 0.539 | 0.595 | 0.86 (0.22–3.44) | 0.832 | |
| GG | 0.054 | 0.081 | 0.59 (0.40–0.87) | 0.008 | 0.053 | 0.068 | 1.33 (0.68–2.62) | 0.407 | ||
| GC | 0.301 | 0.411 | 1.00 | 0.408 | 0.337 | 1.00 | ||||
| Dominant | CC | 0.645 | 0.508 | 0.58 (0.40–0.85) | 0.004 | 0.539 | 0.595 | 1.25 (0.66–2.40) | 0.494 | |
| GG + GC | 0.355 | 0.492 | 1.00 | 0.461 | 0.405 | 1.00 | ||||
| Recessive | GC + CC | 0.946 | 0.919 | 0.67 (0.32–1.39) | 0.279 | 0.947 | 0.932 | 0.77 (0.20–2.99) | 0.703 | |
| GG | 0.054 | 0.081 | 0.66 (0.49–0.89) | 0.007 | 0.053 | 0.068 | 1.12 (0.66–1.89) | 0.683 | ||
| Additive | – | – | – | 0.64 (0.48–0.87) | 0.004 | – | – | 1.11 (0.66–1.89) | 0.687 | |
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)