Table 5.
The relationship of FGFR2 and MGAT5 SNPs with COPD risk stratified by BMI
| Gene | SNP | Model | Genotype | BMI ≤ 24 | |||
|---|---|---|---|---|---|---|---|
| Frequency in case | Frequency in control | OR (95% CI) | p | ||||
| FGFR2 | rs2420915 | Allele | G | 0.586 | 0.627 | 1.00 | |
| A | 0.414 | 0.373 | 1.19 (0.80–1.76) | 0.392 | |||
| Codominant | GG | 0.320 | 0.373 | 1.00 | |||
| AA | 0.148 | 0.120 | 1.58 (0.64–3.92) | 0.324 | |||
| AG | 0.532 | 0.507 | 1.19 (0.65–2.17) | 0.574 | |||
| Dominant | GG | 0.320 | 0.373 | 1.00 | |||
| AA + AG | 0.680 | 0.627 | 1.26 (0.71–2.24) | 0.429 | |||
| Recessive | AG + GG | 0.852 | 0.880 | 1.00 | |||
| AA | 0.148 | 0.120 | 1.43 (0.62–3.31) | 0.406 | |||
| Additive | – | – | – | 1.24 (0.81–1.88) | 0.318 | ||
| FGFR2 | rs1907240 | Allele | A | 0.574 | 0.597 | 1.00 | |
| G | 0.426 | 0.403 | 1.10 (0.75–1.62) | 0.632 | |||
| Codominant | AA | 0.348 | 0.328 | 1.00 | |||
| GG | 0.200 | 0.135 | 1.43 (0.60–3.41) | 0.419 | |||
| GA | 0.452 | 0.537 | 0.79 (0.43–1.46) | 0.452 | |||
| Dominant | AA | 0.348 | 0.328 | 1.00 | |||
| GG + GA | 0.652 | 0.672 | 0.92 (0.51–1.64) | 0.771 | |||
| Recessive | GA + AA | 0.800 | 0.865 | 1.00 | |||
| GG | 0.200 | 0.135 | 1.64 (0.75–3.60) | 0.215 | |||
| Additive | – | – | – | 1.10 (0.75–1.63) | 0.626 | ||
| FGFR2 | rs2257129 | Allele | C | 0.586 | 0.597 | 1.00 | |
| T | 0.414 | 0.403 | 1.05 (0.71–1.54) | 0.824 | |||
| Codominant | CC | 0.341 | 0.328 | 1.00 | |||
| TT | 0.169 | 0.135 | 1.23 (0.51–2.97) | 0.641 | |||
| TC | 0.490 | 0.537 | 0.86 (0.47–1.59) | 0.641 | |||
| Dominant | CC | 0.341 | 0.328 | 1.00 | |||
| TT + TC | 0.659 | 0.672 | 0.94 (0.52–1.68) | 0.827 | |||
| Recessive | TC + CC | 0.831 | 0.865 | 1.00 | |||
| TT | 0.169 | 0.135 | 1.35 (0.61–2.99) | 0.466 | |||
| Additive | – | – | – | 1.05 (0.70–1.57) | 0.811 | ||
| MGAT5 | rs6430491 | Allele | G | 0.639 | 0.604 | 1.00 | |
| A | 0.361 | 0.396 | 0.86 (0.58–1.27) | 0.456 | |||
| Codominant | GG | 0.386 | 0.403 | 1.00 | |||
| AA | 0.108 | 0.194 | 0.48 (0.21–1.08) | 0.075 | |||
| AG | 0.506 | 0.403 | 1.19 (0.65–2.20) | 0.572 | |||
| Dominant | GG | 0.386 | 0.403 | 1.00 | |||
| AA + AG | 0.614 | 0.597 | 0.96 (0.54–1.69) | 0.888 | |||
| Recessive | AG + GG | 0.892 | 0.806 | 1.00 | |||
| AA | 0.108 | 0.194 | 0.43 (0.20–0.920 | 0.029 | |||
| Additive | – | – | – | 0.78 (0.51–1.18) | 0.231 | ||
| MGAT5 | rs2593704 | Allele | C | 0.791 | 0.657 | 1.00 | |
| G | 0.209 | 0.343 | 0.51 (0.33–0.77) | 0.001 | |||
| Codominant | CC | 0.633 | 0.433 | 1.00 | |||
| GG | 0.052 | 0.119 | 0.31 (0.12–0.83) | 0.020 | |||
| GC | 0.315 | 0.448 | 0.52 (0.29–0.94) | 0.031 | |||
| Dominant | CC | 0.633 | 0.433 | 1.00 | |||
| GG + GC | 0.367 | 0.567 | 0.48 (0.27–0.83) | 0.009 | |||
| Recessive | GC + CC | 0.948 | 0.881 | 1.00 | |||
| GG | 0.052 | 0.119 | 0.41 (0.16–1.05) | 0.064 | |||
| Additive | – | – | – | 0.54 (0.36–0.83) | 0.005 | ||
SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)