Table 4.
Univariate and multivariate Cox regression analyses of the four-gene signature and other prognostic factors for recurrence-free survival in TCGA cohort and TFAHCQMU cohort
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Recurrence-free survival | HR | 95%CI | P-value | HR | 95%CI | P-value |
| TCGA cohort | ||||||
| Age (≥60 vs < 60) | 1.080 | 0.770–1.514 | 0.656 | – | – | – |
| vGender (male vs female) | 1.062 | 0.734–1.536 | 0.750 | – | – | – |
| Cirrhosis (positive vs negative) | 1.422 | 0.930–2.176 | 0.104 | – | – | – |
| AJCC stage (III-IV vs I-II) | 2.493 | 1.718–3.616 | < 0.001*** | 2.776 | 1.736–4.440 | < 0.001*** |
| Tumor grade (III-IV vs I-II) | 0.981 | 0.685–1.405 | 0.917 | – | – | – |
| Vascular invasion (positive vs negative) | 1.730 | 1.177–2.541 | 0.005** | 1.113 | 0.741–1.672 | 0.606 |
| Signature (high-risk vs low-risk) | 3.107 | 1.783–5.951 | < 0.001*** | 2.553 | 1.154–5.782 | < 0.001*** |
| TFAHCQMU cohort | ||||||
| Age (≥60 vs < 60) | 1.213 | 0.469–3.134 | 0.995 | – | – | – |
| Gender (male vs female) | 1.012 | 0.381–1.821 | 0.316 | – | – | – |
| Cirrhosis (positive vs negative) | 1.478 | 0.571–3.826 | 0.311 | – | – | – |
| AJCC stage (III-IV vs I-II) | 3.954 | 1.186–9.415 | 0.016* | 2.598 | 1.546–7.109 | 0.042* |
| Tumor grade (III-IV vs I-II) | 1.592 | 0.615–4.11 | 0.129 | – | – | – |
| Vascular invasion (positive vs negative) | 2.012 | 0.785–5.162 | 0.064 | – | – | – |
| Signature (high-risk vs low-risk) | 5.023 | 3.422–9.836 | < 0.001*** | 3.289 | 2.821–8.481 | 0.002** |
RFS,recurrence-free survival; TCGA, The Cancer Genome Atlas; TFAHCQMU, the First Affiliated Hospital of Chongqing medical university; CI,confidence interval; HR,hazard ratio
*P-value< 0.05, **P-value< 0.01, ***P-value< 0.001