Figure 6.

Implantation of 3D printed scaffolds with and without small molecules into the rat model with critical-size mandibular defect. (A) Schematic drawing to show the implantation location; (B) Representative images of the animals with mandibular defects and with implantation of 3D printed scaffolds loaded with RVS and SrRn; (C) Representative micro CT reconstruction images at 8 weeks after surgery in different groups; (D) Micro CT quantification of bone volume to the total volume of the former defect area (BV/TV, n=5–6, *p<0.05, ***p<0.001).