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. 2021 Apr 21;12:247. doi: 10.1186/s13287-021-02133-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Functional recapitulation of human lacrimal gland (LG) organoids. To confirm the secretory function of the organoid, A Ca²⁺ uptake (Magnification; 10×, Scale bar; 100 µm) and B released β-hexosaminidase was detected after 1 μg/mL pilocarpine treatment, and C the secretome released from the organoid was observed via TEM. Proteins secreted by pilocarpine were identified using proteomic analysis. Through the D heatmap, E Venn diagram, F gene ontology (GO) term analysis, and identification of the differentially expressed proteins (DEPs), the proteins were seen to be more secreted from pilocarpine-treated organoids than from the normal organoids, and most proteins belonged to exosome/vehicle