Table 3.
Diagnostic accuracy of plasma Nfl and t-tau in the discrimination of CJD
Plasma Nfl | Plasma t-tau | |||||
---|---|---|---|---|---|---|
CJD vs. | Cutoff | Sensitivity (%) | Specificity (%) | Cutoff | Sensitivity (%) | Specificity (%) |
HC | > 33 pg/mL | 100 | 100 | > 6.0 pg/mL | 84 | 100 |
Non-CJD-Dem | > 70 pg/mL | 79 | 96 | > 6.1 pg/mL | 95 | 84 |
Non-CJD-neurodeg-Dem | > 70 pg/mL | 88 | 96 | > 6.1 pg/mL | 95 | 84 |
Sensitivity (in %), specificity (in %), and associated cutoff points (in pg/mL) for plasma Nfl and t-tau in the discrimination of CJD from HC, non-CJD-Dem, and non-CJD neurodeg-Dem