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. Author manuscript; available in PMC: 2021 Apr 21.
Published in final edited form as: J Thromb Haemost. 2020 Feb 28;18(4):885–894. doi: 10.1111/jth.14744

Figure 1. In reconstituted whole blood with human donor plasma, the FXIII 34Leu variant mitigates the effect of high fibrinogen concentration on contracted clot mass.

Figure 1.

(A) Platelet-poor plasmas from 86 healthy donors (40 FXIIIVal/Val, 28 FXIIIVal/Leu, and 18 FXIIILeu/Leu) were reconstituted with washed platelets and O-negative red blood cells. Clotting was triggered with tissue factor and CaCl2, and contracted clots were weighed after 2 hours. Clot mass was normalized between assays performed on two different days. (B) Normalized clot mass. (C-F) Normalized clot mass were plotted as a function of (C) fibrinogen, (D) age, (E) FXIII activity, (F) prothrombin time, and (G) thrombin generation lag time. Lines indicate linear fits. Symbols are: FXIIIVal/Val (black closed circles), FXIIIVal/Leu (blue half-filled circles), and FXIIILeu/Leu (red open circles).