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. Author manuscript; available in PMC: 2021 Apr 21.
Published in final edited form as: J Thromb Haemost. 2020 Feb 28;18(4):885–894. doi: 10.1111/jth.14744

Figure 2. In reconstituted whole blood with purified FXIII, the FXIII 34Leu variant alters contracted clot mass in a fibrinogen concentration-dependent manner.

Figure 2.

(A) O-negative red blood cells, FXIIIVal/Val platelets, and FXIII-depleted plasma reconstituted with either FXIIIVal/Val or FXIIILeu/Leu zymogen, were combined. FXIII-free fibrinogen (peak 1) was added to reach the final concentrations indicated in panel B. Clotting was triggered with tissue factor and CaCl2, and contracted clots were weighed at 2 hours. (B) Differences between FXIIIVal/Val (black closed circles) and FXIIILeu/Leu (red open circles) clot mass for each fibrinogen concentration were compared by t-test. Data show mean ± standard error of the mean (N=3). *P<0.05