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EC50 values of NA inhibitors against SARS-CoV-2 RdRp.
| Compounds | nsp12 (EC50/μM) | nsp12 + 14 (EC50/μM) | nsp12 + 14(mutant)(EC50/μM) | Ratio of EC50 (12 + 14/12) | Ratio of EC50 (12 + 14(mutant)/12) |
|---|---|---|---|---|---|
| Remdesivir | 1.11 | 2.00 | 1.52 | 1.80 | 1.37 |
| Ribavirin | 112.20 | >1000 | 120.05 | >8.91 | 1.07 |
| Penciclovir | 74.13 | >1000 | 87.55 | >13.49 | 1.18 |
| Favipiravir | 67.61 | 707.95 | 88.30 | 10.47 | 1.31 |
| Entecavir | 109.65 | >1000 | 116.50 | 9.12 | 1.06 |
| Tenofovir | 79.43 | 758.58 | 107.50 | 9.55 | 1.35 |
