Table 2.

Comparison of neuropsychological tests between normal controls and FEDN schizophrenia (between sex)

Cognitive domains	Cognitive tests	Normal controls		FEDN schizophrenia		Diagnosis F (p-value)	Sex F (p-value)	Diagnosis × sex F (p-value)
		Male(n = 74)	Female(n = 86)	Male(n = 45)	Female(n = 48)
Speed of processing	Category fluency	56.8 ± 13.1	52.0 ± 12.2	52.8 ± 9.2	51.5 ± 9.7	2.241(0.136)	3.977(0.047)	1.346(0.247)
	Symbol coding	57.7 ± 9.4*	55.9 ± 11.6	38.4 ± 11.0*++	43.5 ± 9.7++	132.753(< 0.001)	1.447(0.230)	6.354(0.012)
	Trail Making A	56.4 ± 8.2	53.8 ± 9.6	45.5 ± 6.8++	47.3 ± 7.3++	64.223(< 0.001)	0.151(0.698)	4.043(0.045)
Attention	CPT-IP	55.2 ± 7.9	53.5 ± 8.6	40.4 ± 9.7++	44.3 ± 9.5++	108.633(< 0.001)	0.845(0.359)	6.079(0.014)
Working memory	Spatial span total	60.7 ± 11.4	55.1 ± 11.9	43.7 ± 12.1++	48.1 ± 13.2++	58.608(< 0.001)	0.170(0.681)	10.297(0.002)
	Digital sequence	60.2 ± 10.5	54.4 ± 10.5	46.0 ± 10.2*++	50.8 ± 10.1	43.065(< 0.001)	0.138(0.711)	14.873(< 0.001)
Verbal learning	HVLT-R total	59.8 ± 8.8	56.3 ± 10.3	46.7 ± 12.5*++	52.3 ± 9.3+	41.215(< 0.001)	0.654(0.419)	11.823(0.001)
Visual learning	BVMT-R total	57.8 ± 8.2*	54.8 ± 10.4	49.1 ± 9.5++	46.1 ± 10.0++	49.165(< 0.001)	5.762(0.017)	0.000(0.994)
Reasoning and problem solving	Mazes (NAB) total	62.4 ± 7.7**	56.4 ± 11.0	48.9 ± 10.3++	46.6 ± 9.6++	83.328(< 0.001)	10.701(0.001)	2.130(0.146)
Social cognition	MSCEIT	51.8 ± 8.8	51.0 ± 8.3	47.7 ± 11.9+	51.2 ± 11.1	2.432(0.120)	1.112(0.293)	2.740(0.099)
	Total MCCB scores	63.0 ± 10.6	57.2 ± 12.4	44.2 ± 10.0++	47.6 ± 9.7++	97.977(< 0.001)	0.665(0.416)	10.234(0.002)

^*Indicates the comparison between males and females in FEDN schizophrenia or in the controls: ^*p < 0.05, ^**p < 0.01

⁺Indicates the comparison between FEDN schizophrenia and the controls in males or females: ⁺p < 0.05, ⁺⁺p < 0.01