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ClinVar variants of uncertain significance in genes related to IEMs and PGx
(A–D) The number of VUSs in ClinVar between 2015 and 2020 in IEM and PGx genes, respectively (A and B). All ClinVar variants in IEM and PGx genes that were reclassified between February 2018 and February 2019 (C and D). Height of bars is proportional to number of variants reclassified. A total of 293 variant reclassifications is shown in (C), and 434 variant reclassifications are shown in (D).
