Fig. 1.

Bladder CARE workflow. After the test has been ordered, Bladder CARE Urine Collection Kit is directly mailed to the patient’s home address. A stabilization agent (Urine Preservation Reagent; Pangea Laboratory, PNG100-1-35) is added to the urine right after the sample collection in order to preserve the urine DNA integrity for up to one month at room temperature [42]. Upon return mailing, urine samples are processed at Pangea Laboratory and at least 5 ng of urine DNA is analyzed with Bladder CARE test. A sample report is sent to the doctor. Patients can be classified as Negative, High-Risk, and Positive by Bladder CARE