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. 2021 Apr 21;13:84. doi: 10.1186/s13148-021-01029-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Determination of Bladder CARE linearity and LOD. Bladder CARE linearity and LOD: comparison between the number of cancer cells (LD583 cancer cell line [41]) originally present in the 12 spike-in samples (dashed line and numbers above it) and the correspondent Bladder CARE Index (BCI) value (solid line and numbers above it). Each sample was tested using 500 ng of spike-in DNA in three technical replicates. Significant differences in BCI between two consecutive samples are indicated by asterisks below the solid line. n.s. = not significant. Although barely visible, error bars for technical replicates are reported for each spike-in sample. Percentage of cancer cells in each spike-in sample (500 ng, correspondent to approximately 70,000 cells considering that one DNA molecule weighs 3.59 pg [43]) is indicated in the X-axis. BCI value and number of cancer cells are represented in the Y-axis (logarithmic scale)